Can I Combine PRP with Polynucleotides?
Yes, PRP and polynucleotides can be safely and effectively combined, and for many patients this approach delivers superior skin rejuvenation compared to using either treatment alone. At Alcove Aesthetics in Pall Mall, Central London, Dr Goziem Onuchukwu frequently recommends this combination for patients seeking natural, regenerative results rather than dramatic change.
PRP works by using your body’s own growth factors to stimulate repair, while polynucleotides improve cellular function and skin quality at a deeper level. When combined under expert guidance, they support collagen production, hydration, elasticity, and overall skin resilience. This makes the pairing particularly popular with women in their 30s and 40s who want to look refreshed, rested, and healthy without looking overdone.
Introduction
As interest in regenerative aesthetics grows, more patients are asking whether treatments can be layered for better results. PRP and polynucleotides are two of the most scientifically grounded options available, both focused on improving skin health from within rather than masking ageing.
The key is understanding how these treatments work differently, and why combining them can be beneficial when done by a doctor-led facial aesthetics clinic in London. Personalisation and timing are essential to achieve natural results.
What It Is & How It Works
PRP explained
PRP, or platelet-rich plasma, is derived from a small sample of your own blood. After processing, the platelet-rich fraction is injected back into the skin to release growth factors that stimulate healing, collagen production, and tissue repair.
PRP is especially effective for dull skin, early fine lines, uneven texture, and areas such as the under-eyes. Because it uses your own biological material, it is well tolerated and works in harmony with the skin.
You can read more about this treatment here:
https://alcoveaesthetics.com/PRP/
Polynucleotides explained
Polynucleotides are highly purified DNA fragments that improve cellular regeneration, hydration, and skin elasticity. They support fibroblast activity, enhance collagen synthesis, and improve skin quality at a structural level.
Unlike treatments that simply add volume, Polynucleotides strengthen the skin itself, making them ideal for crepey texture, thinning skin, and early signs of ageing. They are commonly used on the face, neck, eyes, and hands.
Learn more about polynucleotide treatments here:
https://alcoveaesthetics.com/polynulceotides-ameela/
Why combining them works
PRP delivers growth factors that signal repair. Polynucleotides create an optimal environment for cells to function and regenerate. Together, they amplify each other’s effects, leading to improved skin quality, better collagen response, and longer-lasting results.
Benefits & Results
Patients who combine PRP with polynucleotides often experience:
- Improved skin texture and elasticity
- Enhanced hydration and natural glow
- Softer fine lines and creases
- Stronger, more resilient skin over time
- Gradual, natural-looking rejuvenation
Results develop progressively, with noticeable improvements over 4 to 8 weeks and continued enhancement as collagen production increases.
Why Choose Alcove Aesthetics
Alcove Aesthetics is a doctor-led Mayfair aesthetic clinic located at 120 Pall Mall, London SW1Y 5EA. All treatments are performed by Dr Goziem Onuchukwu, BDS, MSc (Aesthetic Medicine), a GDC registered dentist with over 7 years of experience and more than 1,000 patients treated.
Dr Goziem is a two-time winner of Best Anti-Ageing Practitioner in Central London for 2024 and 2025, and was named Skin Aesthetics Specialist of the Year in 2025. Her approach focuses on precision, safety, and subtle results that respect each patient’s natural features.
Treatment Journey
Your appointment begins with a comprehensive consultation. Dr Goziem assesses your skin quality, medical history, and aesthetic goals before recommending whether PRP, polynucleotides, or a combination is appropriate.
Treatment may be performed in the same session or staged depending on your skin’s needs. In some cases, regenerative injectables are combined with treatments such as Exosomes to further support healing and collagen stimulation in more advanced skin concerns.
More information on Exosomes can be found here:
https://alcoveaesthetics.com/exosomes/
Follow-up appointments are offered for all treatments to review progress and adjust your plan if needed.
Recovery & Aftercare
Downtime is minimal. Mild redness, swelling, or tenderness can occur for 24 to 48 hours. Most patients return to normal activities the same or next day.
Results are gradual. Skin often looks brighter within a few weeks, with continued improvement in texture and firmness over several months. Aftercare advice is provided to support healing and optimise outcomes.
Cost & Transparency
PRP treatments start from £350 per session or £950 for a course of three. Polynucleotides are £330 for one session or £900 for a course of three. Combined treatment plans are discussed transparently during consultation.
A £50 booking fee is required to secure your appointment. This is redeemable against treatment and subject to a 48-hour reschedule policy.
FAQs
Is it safe to combine PRP and polynucleotides?
Yes, when administered by a qualified doctor following a full assessment.
Do I need both treatments?
Not always. Some patients benefit from one alone, while others achieve better results with a combination.
How many sessions are needed?
Typically a course of 2 to 3 sessions, depending on skin condition and goals.
When will I see results?
Initial improvement appears within weeks, with continued enhancement over several months.
Who is not suitable?
Suitability depends on medical history and skin condition. A consultation is essential.
Combining PRP with polynucleotides offers a powerful yet natural approach to skin rejuvenation when guided by medical expertise. For patients seeking regenerative, long-term skin health rather than quick fixes, this combination can be an excellent option.
To book your personalised consultation with Dr Goziem Onuchukwu at Alcove Aesthetics, Pall Mall, London, call 07856962248 or book online at alcoveaesthetics.com/appointments. Individual results may vary. A full consultation is required to determine suitability.
