Polynucleotides in Central London
Award-Winning Regenerative Skin Treatment at Alcove Aesthetics
If your under-eyes look tired no matter how much sleep you get, or your skin’s losing that bounce it used to have, polynucleotides might be exactly what you need. At Alcove Aesthetics in Pall Mall, Dr Goziem uses medical-grade Plinest and Newest to repair your skin from the inside out- no filler, no “done” look, just healthier, glowing skin that lasts.
✓ Best Anti-Ageing Practitioner 2024 & 2025
✓ Skin Aesthetics Specialist of the Year 2025
✓ 7+ Years Doctor-Led Expertise
✓ Trusted verified professionals
What Are Polynucleotides and How Do They Actually Work?
Here’s the thing about injectables: they’re only as good as the person holding the needle. Dr Goziem Onuchukwu has spent over 7 years perfecting regenerative skin treatments, she’s been named Best Anti-Ageing Practitioner in Central London two years running (2024 and 2025), plus Skin Aesthetics Specialist of the Year 2025.
What makes Dr Goziem different? She doesn’t rush. Every consultation is thorough, every treatment plan is tailored, and she’ll tell you honestly if polynucleotides aren’t right for you.
Our clinic’s at 120 Pall Mall, right in the heart of Central London. It’s a calm, luxurious space where you can actually relax .
But more importantly, it’s where you’ll get expert, doctor-led care that puts your safety and results first.
Why Patients Choose Us:
- 🏆 Award-winning expertise you can actually trust
- 🎓 MSc in Aesthetic Medicine + 7 years in practice
- 📍 Beautiful clinic in Central London (Pall Mall)
- 💬 Honest advice, natural results, zero pressure
- Advanced Skincare
- Personalised Approach
- Trusted Expert
What Can Polynucleotides Actually Fix?
Pretty much any area where your skin’s looking tired, thin, or damaged. Dr Goziem treats under-eyes (our most popular area), full face, neck, décolletage, and even hands. The under-eye – polynucleotides work where traditional filler often can’t, particularly if you’ve got bags or really thin skin that makes filler a bit risky.
Whether you’re dealing with dark circles that won’t budge, crepey eyelids, fine lines creeping in, dull skin, pigmentation, old acne scars, or just general your skin doesn’t look like it used to – polynucleotides can help. They work with your body’s natural healing, so the results develop slowly and stick around.
Areas We Treat:
- Under-eyes (dark circles, thin or crepey skin)
- Full face
- Neck and décolletage
- Hands
Concerns Polynucleotides Address:
- Dark under-eye circles
- Fine lines and early signs of ageing
- Skin that’s lost its firmness
- Dull, tired-looking complexion
- Uneven tone and pigmentation
- Acne scarring and textural issues
What to Expect During Your Polynucleotide Treatment
Consultation
Your journey starts with a thorough consultation with Dr Goziem. She’ll assess your skin, listen carefully to your concerns, and talk you through whether polynucleotides are the right option for you. This is your time to ask questions and feel completely confident in the plan, nothing is rushed, and nothing is too small to ask.
Treatment day
On the day of treatment, the skin is cleansed and a topical numbing cream is applied to keep you comfortable. Once numb, Dr Goziem carefully places the polynucleotide solution using a very fine needle or a blunt-tipped cannula.
For delicate areas such as the under-eyes, a cannula is often used to minimise bruising and swelling.
The procedure typically takes 20–30 minutes, depending on the area being treated.
Immediately after
It’s normal to experience mild redness, slight swelling, or small bumps at the injection points. These are temporary and usually settle within 24–48 hours. Most patients return to normal activities the same or next day.
Results
Polynucleotides work by stimulating your skin’s natural repair processes, so improvements develop gradually rather than overnight.
You may notice early changes within 2–4 weeks, with smoother, brighter, healthier-looking skin.
Full results are usually seen around 12 weeks, once your treatment course is complete.
For best outcomes, Dr Goziem typically recommends 2–3 sessions spaced 2–4 weeks apart, followed by maintenance treatments every 6–9 months.
Your treatment timeline
Consultation – Skin assessment and personalised plan
Treatment day – 20–30 minutes with numbing cream
24–48 hours – Minor swelling settles
2–4 weeks – Early improvements become visible
12 weeks – Full results
6–9 months – Maintenance session to sustain results
- Advanced Skincare
- Personalised Approach
- Trusted Expert
Polynucleotides vs Profhilo, Fillers, and other treatments
If you’ve been researching skin treatments, you’ve probably come across options such as Profhilo, dermal fillers, and a variety of injectable skin boosters, all promising smoother, younger-looking skin. It can quickly become confusing to know which treatment is actually right for you.
The difference comes down to what each treatment is designed to do.
Dermal fillers replace lost volume and restore contour in areas that have hollowed or sagged. Hydrating boosters such as Profhilo improve moisture levels and skin laxity.
Polynucleotides focus on something slightly different. They improve the quality and health of the skin itself.
Rather than adding volume, they work at a cellular level to stimulate tissue repair, calm inflammation, and encourage collagen production and healthy circulation. The result is stronger, more resilient skin that looks fresher and more refined over time.
This regenerative approach makes polynucleotides particularly effective for concerns that are often difficult to treat with filler alone, including under-eye crepiness and dark circles, acne scarring, sun damage, and thinning or fragile skin.
They can also be safely combined with other treatments such as microneedling, lasers, and skin boosters as part of a comprehensive rejuvenation plan.
During your consultation, Dr Goziem will assess your skin carefully and recommend whether polynucleotides alone or a combination approach will give you the most natural, long-lasting results.
FAQ's
Frequently Asked Questions About Polynucleotides
What's the difference between polynucleotides and filler?
Polynucleotides repair your skin and get it producing collagen again, so you get gradual, natural improvement. Filler physically adds volume to specific areas. If you need under-eye skin to thicken up or texture to improve, polynucleotides are your friend. If you’ve got hollow cheeks or deep lines, filler’s better. Sometimes you need both.
Does it hurt?
We use numbing cream, and sometime a local anaesthetic too. Most people describe it as mild pressure or little pinches. Dr Goziem usually uses a blunt cannula for under-eyes which makes it much more comfortable and reduces bruising.
How many sessions do I need?
Usually 2-3 sessions, spaced 4-6 weeks apart. After that, maintenance every 6-9 months keeps your results going strong.
When will I actually see a difference?
You’ll notice early changes around 2-4 weeks in, but the full effect develops over 12 weeks as your collagen ramps up. Results last 6-9 months.
Will I need time off work?
No. You might have some redness or swelling for a day or two, but most people go straight back to their day. Just avoid the gym, alcohol, and saunas for 24 hours.
Can you use polynucleotides under the eyes?
Absolutely, it’s one of the best areas for them. They’re perfect for dark circles, thin skin, and fine lines, especially if you’re not a good candidate for tear trough filler because of under-eye bags.
Are they safe?
Very. Polynucleotides have been used in medicine since the 1980s. The DNA fragments are purified and biocompatible. Serious side effects are rare, especially with an experienced doctor.
Who can't have polynucleotides?
They’re made from fish DNA, so they’re not suitable for anyone with a fish allergy. Also not suitable if you’re pregnant or breastfeeding. Dr Goziem will go through all this in your consultation.
Can I combine them with other treatments?
Yes! They work really well alongside microneedling, skin boosters, lasers, and filler. Dr Goziem will put together a plan based on what you’re trying to achieve.
How Much Do Polynucleotides Cost in London?
We believe in clear, transparent pricing, with no hidden fees or unexpected add-ons.
A single polynucleotide session is £330, or you can choose a course of three for £900, saving £90.
Your consultation deposit is fully deductible from your treatment cost.
Pricing
Single session: £330
Course of 3 sessions: £900 (save £90)
Consultation deposit: deducted from treatment cost
Dr Goziem’s diary fills 4-6 weeks in advance. Secure your spot early.
Before and After Results
Visit Alcove Aesthetics in Central London
We’re at 120 Pall Mall, right in the heart of Central London, seconds from St James’s Park and easy to reach from anywhere in the city.
Nearest Tubes:
Piccadilly Circus, Charing Cross, Green Park.
Alcove Aesthetics by Dr Goziem
120 Pall Mall, London, SW1Y 5EA
Polynucleotide Treatment Summary
- Duration - (30 Minutes)
- Results Show - (7-14 Days)
- Results Last - Ungoing, 8 - 12 months)
- Down Time - (24 - 72 Hours)
- Anaesthetic - (Not Required)
- Side Effects - (Possible Localised swelling and Bruising)
Ready to See What Polynucleotides Can Do for Your Skin?
Book your consultation with Dr Goziem and find out how polynucleotide treatment can give you naturally healthier, glowing skin that actually lasts.
