The expert comparison from London’s doctor-led facial aesthetics clinic
If you’re searching for the best way to improve skin elasticity, hydration and collagen production in Central London, you’ve likely come across Profhilo and Polynucleotides. Both are injectable skin rejuvenation treatments known for their ability to restore youthful firmness without altering facial structure.
At Alcove Aesthetics by Dr Goziem, patients often ask: Which works better for collagen – Profhilo or Polynucleotides? The answer depends on your skin’s needs and desired results. Here, Dr Goziem Onuchukwu (BDS, MSc Aesthetic Medicine) explains the science, benefits and ideal use for each, helping you make a confident choice at our Pall Mall aesthetic clinic, near Mayfair and Westminster.
Understanding the Demand for Natural Skin Rejuvenation
More patients today want visibly refreshed, tighter skin without the frozen or “filled” look. Treatments like Profhilo and Polynucleotides are leading this movement towards regenerative, doctor-led aesthetics – supporting the skin’s own ability to repair, hydrate and firm naturally.
At Alcove Aesthetics, every treatment is guided by a medical eye for harmony, balance and safety. With over 1,000 patients treated and awards including Best Anti-Ageing Practitioner (Central London 2024 & 2025), Dr Goziem focuses on subtle, long-lasting rejuvenation that enhances confidence, not features.
What Are Profhilo and Polynucleotides?
Profhilo – Bioremodelling with Hyaluronic Acid
Profhilo is a high-purity injectable skin booster made from stabilised hyaluronic acid (HA). Unlike fillers, it doesn’t add volume. Instead, it spreads evenly across the skin to deeply hydrate and trigger collagen and elastin synthesis.
Once injected, Profhilo activates fibroblast cells – the skin’s collagen factories – leading to firmer, plumper and more luminous skin over several weeks. It’s often described as a “liquid moisturiser” that remodels the skin from within.
Common treatment areas:
- Face and jawline
- Neck and décolletage
- Hands and arms
Typical treatment plan: 2 sessions spaced 4 weeks apart (£300 single | £550 course of 2)
Polynucleotides – Regenerative Biostimulators
Polynucleotides (PN) are a newer generation of regenerative injectables derived from purified DNA fragments. They work on a cellular level to repair damaged tissue, improve hydration, and stimulate collagen, elastin and fibroblast activity – all while calming inflammation and oxidative stress.
PNs act as biostimulators rather than fillers or hydrators, helping the skin restore its natural function. Over time, they improve texture, tone and resilience, making them ideal for tired, thinning or environmentally stressed skin.
Common treatment areas:
- Face, under-eyes, neck
- Acne scars and pigmentation
- Fine lines and crepey skin
Typical treatment plan: 3 sessions spaced 3–4 weeks apart (£330 single | £900 course of 3)
How They Work: A Scientific Comparison
| Treatment | Main Ingredient | Mechanism | Primary Effect | Best For |
|---|---|---|---|---|
| Profhilo | Hyaluronic acid | Deep hydration + collagen stimulation | Plumper, smoother, dewier skin | Dehydrated, dull, crepey skin |
| Polynucleotides | Purified DNA fragments | Cellular regeneration + fibroblast repair | Stronger, firmer, more elastic skin | Ageing, damaged, or inflamed skin |
While Profhilo offers an instant hydration glow, Polynucleotides provide longer-term structural rejuvenation through deep cellular repair. Many patients combine both treatments for a comprehensive regeneration plan.
Benefits and Results
Both treatments are designed to boost collagen naturally, but each has unique strengths.
Profhilo Benefits
- Intense hydration and glow
- Improved skin elasticity
- Softer fine lines and creases
- Quick results with minimal downtime
Polynucleotide Benefits
- Enhanced collagen and elastin formation
- Improved skin firmness and density
- Anti-inflammatory and antioxidant action
- Long-term tissue repair and regeneration
At Alcove Aesthetics, Dr Goziem often recommends Profhilo for immediate radiance and Polynucleotides for deeper rejuvenation and repair, depending on your skin goals.
Why Choose Alcove Aesthetics in Central London
Choosing a doctor-led clinic ensures every injection is performed with medical precision and tailored understanding of facial anatomy.
At Alcove Aesthetics by Dr Goziem, you benefit from:
- Over 7 years’ experience and advanced MSc training in Aesthetic Medicine
- Award-winning expertise in skin rejuvenation and anti-ageing
- A discreet Central London location at 120 Pall Mall, near Mayfair, St James’s and Knightsbridge
- Follow-up reviews and personalised aftercare for every patient
Dr Goziem’s technique prioritises natural harmony – ensuring your results are fresh and authentic, never overdone.
Your Treatment Journey
- Consultation:
Every treatment begins with a detailed consultation with Dr Goziem Onuchukwu, assessing your skin’s hydration, texture and collagen levels. - Treatment:
- Profhilo is delivered using the BAP technique across five key points on each side of the face.
- Polynucleotides are injected into targeted areas for precise regeneration.
Both treatments take around 30 minutes and are performed with ultra-fine needles for minimal discomfort.
- Follow-Up:
You’ll be invited for review after your course to assess progress and plan maintenance.
Recovery and Aftercare
Both Profhilo and Polynucleotides have minimal downtime. You may experience slight redness or swelling at injection sites for 12–24 hours. Makeup can be worn after 24 hours, and normal activities can resume the same day.
Results timeline:
- Profhilo: visible glow within 1 week, firmer skin by 4–6 weeks
- Polynucleotides: gradual improvement over 3 sessions, with peak results at 2–3 months
Dr Goziem provides full aftercare guidance to maintain and enhance results.
Cost and Transparency
At Alcove Aesthetics, pricing reflects doctor-led care and the highest quality products.
- Profhilo: £300 (1 session) | £550 (2 sessions)
- Polynucleotides: £330 (1 session) | £900 (3 sessions)
A £50 booking fee secures your consultation and is redeemable against treatment. A 48-hour reschedule policy applies.
Frequently Asked Questions
Is one treatment better than the other for collagen?
Polynucleotides tend to offer deeper, longer-lasting collagen stimulation, while Profhilo delivers faster hydration and glow. Many patients benefit from combining both.
Can they be used together?
Yes. Profhilo and Polynucleotides work synergistically. Dr Goziem often alternates them in a regenerative plan for optimal results.
Are they safe for all skin types?
Yes. Both are biocompatible and well-tolerated, suitable for all skin tones and ages, following consultation.
Do results look natural?
Absolutely. These are regenerative, non-volumising treatments that enhance skin quality without changing your facial shape.
How long do results last?
Profhilo results typically last 6 months, while Polynucleotide results can last 9–12 months with proper maintenance.
Ready to Boost Your Collagen Naturally?
To book your personalised consultation with Dr Goziem Onuchukwu at Alcove Aesthetics, 120 Pall Mall, London SW1Y 5EA, call 07457 404 982 or book online at alcoveaesthetics.com/appointments.
All treatments are doctor-administered. Individual results may vary. A consultation is required to determine suitability.
