Doctor-led regenerative skin rejuvenation in Mayfair, London
If your skin is starting to look tired, dull or less elastic, it may be time to move beyond surface treatments and focus on regeneration. Polynucleotide therapy is one of the most advanced anti-ageing treatments available designed to heal, hydrate and rebuild skin from within.
At Alcove Aesthetics by Dr Goziem Onuchukwu, we use premium medical-grade polynucleotides to restore collagen, firmness and radiance naturally. Here are five key signs your skin could benefit from this breakthrough treatment.
1. Your Skin Feels Thinner or Less Elastic
Loss of elasticity is one of the earliest indicators of collagen decline. Polynucleotides stimulate fibroblast activity, encouraging the skin to produce new collagen and elastin — the structural proteins that keep skin supple and firm.
Patients notice their skin feels thicker, more resilient and youthful within a few weeks of treatment.
2. You Have Fine Lines That Don’t Smooth with Moisturiser
When topical products no longer make a difference, it’s often because hydration can’t reach the deeper dermal layers. Polynucleotides work on a cellular level to repair and rehydrate skin from within, improving texture and reducing fine lines without adding volume.
Dr Goziem frequently recommends polynucleotides for patients who want to refresh their under-eye area or early signs of ageing around the mouth and cheeks.
3. You’re Noticing Dullness or Uneven Tone
Skin that looks grey or fatigued often lacks oxygen and microcirculation. Polynucleotides boost tissue regeneration and cell turnover, revealing a smoother, more luminous complexion.
At Alcove Aesthetics, patients often see visible brightness after just one session, with optimal radiance after a course of three.
4. You’ve Tried Fillers or Skin Boosters but Want a More Natural Option
Unlike fillers, which add volume, polynucleotides encourage your skin to rejuvenate itself. They’re ideal if you prefer gradual, subtle enhancement rather than an instantly plumped look.
Dr Goziem sometimes combines polynucleotides with Skin Boosters or PRP to optimise hydration and collagen response for long-term skin health.
5. You Want to Prevent Early Signs of Ageing
Prevention is key. Starting regenerative treatments in your 30s or 40s can maintain collagen reserves and slow visible ageing. Polynucleotides help preserve firmness, refine pores and maintain that healthy “glow” long-term.
How Polynucleotides Work
Polynucleotides are highly purified DNA fragments (usually derived from salmon) that activate the skin’s natural healing processes. When injected into targeted areas, they:
- Improve cell regeneration and hydration
- Stimulate fibroblasts to produce collagen and elastin
- Strengthen the extracellular matrix
- Reduce inflammation and oxidative stress
At Alcove Aesthetics, all treatments are doctor-administered by Dr Goziem Onuchukwu BDS, MSc (Aesthetic Medicine) – ensuring precision and safety throughout.
Treatment Areas
- Under-eye fine lines and dark circles
- Face and neck rejuvenation
- Crepey skin on cheeks or décolletage
- Scarring or texture irregularities
Treatment Benefits
| Benefit | What to Expect |
|---|---|
| Collagen stimulation | Firmer, lifted skin over 3–6 weeks |
| Cellular repair | Healthier, thicker dermis |
| Hydration boost | Smoother, more luminous complexion |
| Brightening | Reduced dullness and fatigue |
| Regeneration | Long-term improvement with minimal downtime |
Why Choose Alcove Aesthetics
- Doctor-led precision: Every treatment delivered personally by Dr Goziem Onuchukwu, GDC-registered aesthetic practitioner
- Award-winning expertise: Best Anti-Ageing Practitioner (Central London 2024 & 2025); Skin Aesthetics Specialist of the Year (2025)
- Trusted results: Over 1,000 patients treated with natural, regenerative techniques
- Prime location: 120 Pall Mall, serving Mayfair, St James’s, Westminster, Belgravia, Knightsbridge, Chelsea and Soho
Our clinic ethos: science-based rejuvenation that looks elegant and effortless.
Treatment Journey
- Consultation: Dr Goziem assesses your skin’s hydration, elasticity and tone.
- Treatment: Polynucleotides are injected using ultra-fine needles in key areas to stimulate repair.
- Aftercare: Avoid makeup and heat for 24 hours; apply SPF 50 daily.
- Follow-up: Review appointments ensure optimal results and adjustment if needed.
Recovery and Results
Mild redness or swelling can appear for a few hours post-treatment. Most patients notice initial improvement within two weeks, with collagen renewal continuing for up to 12 weeks.
Cost and Transparency
| Treatment | Price |
|---|---|
| 1 Session | £330 |
| Course of 3 | £900 |
A £50 booking fee is required to secure your appointment and is redeemable against treatment.
Frequently Asked Questions
Is it safe?
Yes. Polynucleotides are biocompatible and clinically proven for skin rejuvenation.
How many sessions will I need?
Typically 3 sessions, 2–3 weeks apart, followed by maintenance every 6 months.
Can I combine this with other treatments?
Yes. Dr Goziem often combines Polynucleotides with PRP, Skin Boosters, or Microneedling for enhanced results.
Who isn’t suitable?
Those pregnant, breastfeeding or with active skin infections should postpone treatment until cleared.
Refresh and Regenerate Your Skin with Dr Goziem
If your skin feels tired or lacks vitality, Polynucleotides can restore balance, hydration and glow from within.
To book your consultation with Dr Goziem Onuchukwu at Alcove Aesthetics, 120 Pall Mall, London SW1Y 5EA, call 07457 404 982, email info@drgoziem.com, or visit alcoveaesthetics.com/appointments.
