Cost of Polynucleotides in Mayfair: Is It Worth It?

If you are researching the cost of polynucleotides in Mayfair or Central London, you are usually asking one core question: is it genuinely worth the investment compared with other aesthetic treatments? For many of my patients at Alcove Aesthetics on Pall Mall, the answer is yes, provided your main concerns are fine lines, under eye hollows, crepey skin and a tired, dull complexion, and you are looking for subtle, natural rejuvenation rather than a “filled” look.

At Alcove Aesthetics by Dr Goziem, polynucleotides start at £330 for a single session or £900 for a course of three. For most women in their 30s to 60s, I recommend a course for best collagen stimulation and long term results. When you factor in the quality of the product, doctor-led technique, safety, and how long results last, polynucleotides can be one of the most cost-effective regenerative treatments available in Mayfair and Central London.

This guide explains exactly how polynucleotides work, what they cost, what to expect from your results, and how to decide if they are the right option for you.

Introduction: Why so many women are turning to regenerative treatments

If you are noticing fine lines that were not there a year ago, deepening tear troughs, or skin that looks tired even after a good night’s sleep, you are not alone. From our Mayfair and Westminster patients, the most common request is simple: “I want to look fresher, but still like myself.”

Many women are now moving away from heavy filler and towards regenerative treatments that support the skin’s own biology. Rather than “adding volume,” these treatments aim to improve skin quality, texture, and elasticity from the inside out.

Polynucleotides are part of this new generation of regenerative aesthetics. At my doctor-led facial aesthetics clinic in London, they are particularly popular for the delicate under eye area and for women who want subtle, refined, low downtime rejuvenation that still looks entirely natural.

What It Is & How It Works

Polynucleotides are highly purified chains of nucleotides – the building blocks of DNA and RNA. When carefully injected into the skin, they act as powerful bio-stimulators, encouraging your own cells to repair, regenerate and behave in a more “youthful” way.

The science in clear language

In healthy, youthful skin, fibroblast cells are active, continually producing collagen, elastin and hyaluronic acid. With age, UV exposure, stress and lifestyle, fibroblasts slow down and collagen breaks down faster than it is replaced. The result is thinner, looser skin and fine lines.

Polynucleotides work by:

• Stimulating fibroblasts to produce new collagen and elastin
• Improving microcirculation, so the skin receives more oxygen and nutrients
• Increasing hydration by attracting and holding water in the dermis
• Reducing inflammation and oxidative stress, which can worsen ageing and pigmentation

Over a series of sessions, this combination can lead to thicker, more resilient skin with better tone and luminosity. Unlike traditional Dermal Fillers, polynucleotides are not about creating volume or changing facial shape. Instead, they focus on skin quality and structure.

Where polynucleotides are used

Common treatment areas include:

• Under eyes and tear troughs
• Full face for general skin quality
• Neck and décolletage
• Acne-scarred or crepey skin
• Areas of sun damage

At Alcove Aesthetics in central London, all treatments are performed personally by me, Dr Goziem Onuchukwu, a GDC registered dentist with a Master’s degree in Aesthetic Medicine and over 7 years of experience and 1,000+ patients treated. Every treatment plan is bespoke, based on your skin assessment, lifestyle and goals.

Benefits & Results

Polynucleotides are a medical-grade treatment, and results build gradually over weeks. For many Mayfair and Westminster patients, the key advantages are:

• Natural looking

• No “overfilled” or puffy appearance

• You look fresher, not “done”

• Targeted under eye rejuvenation

• Softens dark circles due to thin, hollow skin

• Reduces crepey texture and fine lines

• Improved skin quality

• Firmer, more elastic skin

• Smoother texture and more even tone

• Hydration from within

• Plumper, healthier looking skin

• Better light reflection and glow

• Regenerative effect

• Stimulates your own collagen and elastin

• Supports long term skin health

• Minimal downtime

• Typically mild swelling or tiny bumps that settle within hours to a couple of days

Most patients start to see changes from week 3, with clearer improvements after a full course of treatments.

Why Choose Alcove Aesthetics

When you are investing in your face, who treats you matters as much as what you choose.

At Alcove Aesthetics by Dr Goziem, based at 120 Pall Mall in the heart of Central London, you are treated in a discreet, doctor-led Mayfair aesthetic clinic environment with a strong focus on safety, precision and natural results.

Key reasons patients travel from Mayfair, Knightsbridge, Belgravia and beyond:

• Doctor-led expertise

• All treatments are performed by me, Dr Goziem Onuchukwu, BDS, MSc (Aesthetic Medicine), GDC registered

• 7+ years experience in facial aesthetics with over 1,000 patients treated

• Award-winning practitioner

• Best Anti-Ageing Practitioner (Central London 2024 & 2025)

• Skin Aesthetics Specialist of the Year (2025)

• Natural, bespoke results

• Detailed facial assessment before any treatment

• Subtle, balanced improvements that respect your own features

• Central London convenience

• Located on Pall Mall, serving Mayfair, St James’s, Westminster, Soho, Marylebone and surrounding areas

• Monday to Friday, 10:00 – 19:00 with evening appointments available

• Comprehensive aftercare

• Follow-up appointments offered as standard

• Clear, written aftercare guidance and direct contact if you have concerns

Treatment Journey

Understanding exactly what to expect helps you decide if the treatment – and its cost – is right for you.

1. Consultation

Your journey begins with a detailed consultation at our facial aesthetics clinic in London. We will:

• Discuss your concerns, medical history and previous treatments
• Assess your skin quality, thickness and elasticity
• Identify whether polynucleotides alone are suitable, or whether they should be combined with other options such as PRP or Sculptra
• Create a staged plan with clear expected timelines and costs

You will have time to ask questions, and there is never any pressure to proceed.

2. Treatment

On the day of treatment:

• Your skin is thoroughly cleansed and prepped
• A topical numbing cream can be applied for comfort, particularly in sensitive areas such as under the eyes
• Polynucleotides are injected in tiny amounts using fine needles or cannulas, depending on the area
• The procedure typically takes 20 to 40 minutes

You may notice small “blebs” or bumps at the injection sites immediately after treatment. These usually settle within a few hours to 48 hours.

3. Follow-up and maintenance

For most patients:

• A course of 2 to 3 sessions, spaced 3 to 4 weeks apart, is recommended initially
• Maintenance sessions are usually suggested every 6 to 12 months, depending on your skin and lifestyle

Review appointments are available so we can assess your progress, refine your plan and answer any questions that arise after your first treatment.

Recovery & Aftercare

Polynucleotides are a low downtime treatment, which is one reason they are so popular with our Central London professional clients.

Typical recovery:

• Mild redness, pinprick marks or small bumps for up to 24 to 48 hours
• Occasional light bruising, which can be covered with concealer after 24 hours

Basic aftercare usually includes:

• Avoiding makeup for at least 12 hours
• No strenuous exercise, saunas or steam rooms for 24 to 48 hours
• Gentle skincare and strict sunscreen use

Results develop gradually, with most people seeing visible changes from week 3, and further improvement after each subsequent session.

Cost & Transparency

At Alcove Aesthetics in Pall Mall, the cost of polynucleotides is:

• £330 for 1 session
• £900 for a course of 3 sessions

For comparison, many of our advanced regenerative treatments in Central London, such as Microneedling or exosomes, are in a similar range. During your consultation, we will clearly outline how many sessions you are likely to need, any combination treatments recommended, and the total investment over time, so you can make an informed decision.

A £50 booking fee is required to secure your appointment, which is fully redeemable against treatment, with a 48 hour reschedule policy. All treatments are doctor-administered, and a full consultation is required to confirm suitability. Individual results may vary.

Frequently Asked Questions

Are polynucleotides safe?

Polynucleotides used in reputable Mayfair aesthetic clinics are highly purified medical products with an excellent safety profile when administered by an experienced medical practitioner. As with any injectable treatment, there is a small risk of bruising, swelling or infection, but serious complications are rare when appropriate technique, hygiene and aftercare are followed.

Do polynucleotides hurt?

Most patients describe the treatment as mildly uncomfortable rather than painful. The under eye area can be more sensitive, but topical numbing cream and very fine needles or cannulas help keep discomfort to a minimum. Treatments are generally well tolerated, even for those who are nervous about needles.

How soon will I see results, and how long do they last?

You may notice slight hydration and plumpness within a week, but the most meaningful results come from collagen stimulation, which takes time. Expect visible improvement from around 3 to 4 weeks after your first session, building further after each treatment in your course. Results can last 6 to 12 months, depending on your age, skin condition and lifestyle.

Who is a good candidate for polynucleotides?

Polynucleotides are ideal for women and men who want to improve skin quality, especially under the eyes, without adding excessive volume. They suit those with fine lines, crepey skin, mild laxity or early signs of ageing. They may not be sufficient alone for very deep volume loss or severe sagging, where a combination approach with fillers or collagen stimulators is often better. A full consultation with me is essential to assess suitability.

How do polynucleotides compare with other treatments like PRP or skin boosters?

PRP uses your own blood platelets to stimulate healing, while hyaluronic acid Skin Boosters focus more on hydration and elasticity. Polynucleotides offer a strong regenerative effect with specific action on fibroblasts and collagen production. In many cases, the most effective strategy is a tailored combination, planned carefully to address your individual concerns, budget and downtime.

To explore whether polynucleotides are the right investment for your skin concerns, and to receive a personalised plan from an award-winning, doctor-led clinic in Central London, I recommend a detailed consultation.

To book your personalised consultation with Dr Goziem Onuchukwu at Alcove Aesthetics, Pall Mall, London, call 07856962248 or book online at alcoveaesthetics.com/appointments.