Polynucleotides have become one of the most talked-about regenerative treatments in London’s medical aesthetics scene, and for good reason. At Alcove Aesthetics by Dr Goziem, located at 120 Pall Mall in Central London, this advanced therapy helps restore youthful skin by activating your body’s own repair mechanisms – all without changing your facial expression or volume.
If you’ve been searching for a doctor-led aesthetic clinic in Mayfair or Westminster offering science-backed rejuvenation, polynucleotides are a leading choice for natural, long-term skin renewal.
Why People Are Turning to Regenerative Treatments
Modern aesthetics has moved beyond surface-level correction. Patients now want treatments that improve skin health, not just appearance. Unlike fillers or Botox that target specific lines or muscles, polynucleotides rebuild the foundation of the skin itself.
This makes them ideal for those noticing early signs of ageing, tired-looking skin, or a dull complexion that needs revitalising without adding volume or altering natural features.
What Are Polynucleotides?
Polynucleotides are purified DNA fragments derived from natural sources such as salmon or trout DNA, chosen for their close compatibility with human tissue. When injected into the skin, they act as biostimulators — substances that encourage your cells to regenerate, repair, and restore balance.
Think of them as a biological “reset” for your skin. Rather than filling lines, they wake up fibroblasts, increase collagen and elastin production, and enhance deep hydration for smoother, firmer, and more radiant skin.
How Polynucleotides Work – The Science Simplified
The process behind polynucleotide therapy is deeply scientific, but it can be explained simply in four key steps:
- Cellular Activation
Polynucleotides send biochemical signals that stimulate fibroblasts — the skin’s repair cells. These fibroblasts begin producing new collagen, elastin, and hyaluronic acid, which are essential for structure and hydration. - Antioxidant Protection
They neutralise free radicals that accelerate ageing, reducing oxidative stress caused by sun exposure and pollution. - Tissue Regeneration
The treatment improves microcirculation and promotes the formation of new blood vessels, enhancing oxygen delivery and nutrient flow to the skin. - Long-Term Rejuvenation
Over time, the skin becomes thicker, stronger, and better hydrated. Fine lines soften, and the complexion appears brighter and smoother.
Clinical Insight from Dr Goziem
“Polynucleotides are one of the most elegant ways to restore skin function. They don’t force change; they encourage your skin to heal and regenerate as it did when you were younger.”
— Dr Goziem Onuchukwu, BDS, MSc (Aesthetic Medicine)
Key Benefits of Polynucleotide Therapy
| Benefit | What It Targets | Results Timeline |
|---|---|---|
| Improved Skin Elasticity | Sagging or laxity | Visible after 3–4 weeks |
| Hydration and Glow | Dry, dull skin | Immediate improvement |
| Fine Line Reduction | Early ageing signs | After 2–3 sessions |
| Under-Eye Rejuvenation | Dark circles or tired appearance | Progressive over 6–8 weeks |
| Texture Refinement | Scars and uneven tone | Gradual smoothing |
Patients often combine polynucleotides with Exosomes, PRP (Platelet-Rich Plasma), or Skin Boosters for enhanced regenerative synergy – all available at Alcove Aesthetics, Pall Mall.
Why Choose a Doctor-Led Clinic for Polynucleotides
At Alcove Aesthetics, every treatment is performed personally by Dr Goziem Onuchukwu, a GDC-registered aesthetic doctor with more than 7 years of clinical experience and over 1,000 patients treated.
Dr Goziem’s credentials include:
- BDS, MSc in Aesthetic Medicine
- Winner: Best Anti-Ageing Practitioner (Central London 2024 & 2025)
- Skin Aesthetics Specialist of the Year (2025)
This ensures your treatment plan is guided by medical expertise, facial anatomy precision, and a commitment to achieving natural, balanced results.
What to Expect During Treatment
- Consultation
A detailed consultation identifies your concerns and determines whether polynucleotides, PRP, or exosomes are most suitable for your goals. - Preparation
After cleansing, a topical anaesthetic is applied for comfort. - Injection Technique
Using fine micro-needles, Dr Goziem injects the polynucleotide solution strategically across the treatment area — often the face, under-eyes, neck, or décolletage. - Duration
The procedure takes around 30 minutes. You may notice mild redness or small bumps immediately after, which settle within 24–48 hours. - Aftercare
You’ll receive personalised advice and a follow-up review to monitor your progress.
Recovery and Results
Polynucleotide treatments are known for minimal downtime. You can resume most activities the same day, though it’s best to avoid heavy exercise or makeup for 24 hours.
Results build gradually, with the most visible improvement around 6–8 weeks after starting your treatment course. For optimal outcomes, Dr Goziem recommends a series of 3 sessions, spaced 3–4 weeks apart, followed by maintenance every 6–9 months.
Cost and Transparency
Alcove Aesthetics is proud to offer clear, upfront pricing for all regenerative treatments:
- £330 per session
- £900 for a course of 3 sessions
Consultations require a £50 booking fee, redeemable against treatment.
Appointments are available Monday to Friday, 10:00 – 19:00, with evening sessions available upon request.
Frequently Asked Questions
Is the treatment safe?
Yes. Polynucleotides are biocompatible and widely used in regenerative medicine. At Alcove Aesthetics, only CE-certified products are used under strict medical supervision.
Will I look overfilled or puffy?
No. Polynucleotides do not add volume — they enhance your skin’s natural structure and vitality.
How long do results last?
Typically 6–12 months, depending on skin type and lifestyle.
Can I combine this with PRP or Exosomes?
Absolutely. Many patients combine polynucleotides with PRP or Exosome therapy for enhanced repair and collagen stimulation.
Who is not suitable?
Patients with active skin infections or certain medical conditions may be advised to delay treatment. A full consultation will confirm suitability.
Book Your Polynucleotide Consultation in Central London
Discover the science behind naturally radiant, youthful skin with doctor-led polynucleotide therapy at Alcove Aesthetics, Pall Mall.
To book your personalised consultation with Dr Goziem Onuchukwu, call 07457 404 982, email info@drgoziem.com, or book online at alcoveaesthetics.com/appointments.
Disclaimer: Individual results may vary. A full consultation with Dr Goziem Onuchukwu is required to determine suitability. All treatments are doctor-administered at Alcove Aesthetics, 120 Pall Mall, London SW1Y 5EA.
