Two of the most advanced regenerative treatments in aesthetic medicine today are Profhilo and polynucleotides, both offering revolutionary approaches to skin rejuvenation that go beyond traditional cosmetic procedures. While both treatments focus on natural skin improvement and regeneration, they work through different mechanisms and offer distinct benefits. Dr. Goziem at Alcove Aesthetics brings her expertise in advanced aesthetic treatments to help patients across St James, Mayfair, Westminster, and Central London understand these innovative options and choose the most suitable approach for their individual needs.
Understanding the Fundamentals
Both Profhilo and polynucleotides represent cutting-edge developments in regenerative aesthetics, moving away from simply filling or masking concerns toward actually improving skin health and function at the cellular level.
Dr. Goziem, with her Master’s degree in Aesthetic Medicine from Queen Mary University of London (graduated with distinction), explains: “These treatments represent the future of aesthetic medicine – working with the body’s natural processes to create genuine improvement in skin quality. Understanding their different mechanisms helps patients make informed decisions about which approach best suits their skin goals and lifestyle.”
Profhilo: Bio-Remodelling Through Hyaluronic Acid
Profhilo contains one of the highest concentrations of hyaluronic acid available in aesthetic medicine, formulated using a unique thermal cross-linking process that creates stable hybrid complexes. This innovative formulation allows the product to spread naturally through tissue whilst stimulating bio-remodelling processes.
How Profhilo Works
Profhilo works through bio-remodelling, stimulating the production of collagen, elastin, and natural hyaluronic acid within the skin. The treatment releases hyaluronic acid slowly into surrounding tissue, triggering cellular responses that enhance skin regeneration and improve overall skin quality.
Primary Benefits of Profhilo
The treatment provides intense hydration through high-concentration hyaluronic acid, stimulates natural collagen and elastin production, improves skin elasticity and firmness, and enhances overall skin quality and radiance. Results typically develop over 8-12 weeks and last 6-9 months.
Polynucleotides: Cellular Regeneration Through DNA Fragments
Polynucleotides are purified DNA fragments that work at the cellular level to stimulate natural skin repair and regeneration processes. These bioactive molecules provide the building blocks that cells need for optimal function, encouraging cellular renewal and tissue repair.
How Polynucleotides Work
Polynucleotides promote cellular repair and regeneration by providing molecular building blocks for optimal cellular function. They stimulate microcirculation, promote new blood vessel formation, stimulate natural collagen production, and possess anti-inflammatory properties that support healing and regeneration.
Primary Benefits of Polynucleotides
The treatment enhances cellular renewal and repair processes, improves circulation and oxygen delivery, stimulates collagen production naturally, reduces inflammation and supports healing, and creates long-lasting improvements in skin quality and health.
Key Differences in Mechanism
Molecular Approach
Profhilo works primarily through hyaluronic acid delivery and bio-remodelling stimulation, whilst polynucleotides work through DNA fragment delivery that provides cellular building blocks for repair and regeneration. Both approaches stimulate natural processes but through different molecular pathways.
Timeline of Action
Profhilo provides more immediate hydration benefits with progressive bio-remodelling over 8-12 weeks. Polynucleotides typically show initial improvement within 1-2 weeks with progressive enhancement over 8-12 weeks as cellular regeneration processes develop.
Longevity Patterns
Profhilo results typically last 6-9 months with maintenance treatments recommended. Polynucleotide benefits can last 6-9 months or longer, with some patients experiencing extended benefits due to the cellular regeneration stimulated by treatment.
Treatment Application and Technique
Profhilo Treatment Protocol
Dr. Goziem administers Profhilo using the BAP (Bio Aesthetic Points) method, involving injection at five specific points on each side of the face. Most patients require two treatments spaced four weeks apart for optimal results, with maintenance every 6-9 months.
Polynucleotide Treatment Protocol
Polynucleotides can be administered through various techniques including direct injection into targeted areas, topical application following microneedling, or combination approaches. Treatment frequency varies based on individual needs and response patterns.
Professional Expertise Requirements
Both treatments require significant expertise for optimal results. Dr. Goziem’s background in oral and maxillofacial surgery at Cambridge University Hospitals provides the anatomical knowledge essential for precise administration of either treatment, ensuring safety and effectiveness.
Comparative Benefits Analysis
Hydration and Skin Quality
Profhilo excels in providing intense, immediate hydration whilst building long-term skin quality improvement. Polynucleotides focus more on cellular repair and regeneration, which indirectly improves hydration through enhanced skin function and barrier repair.
Anti-Aging Effects
Both treatments address aging through natural stimulation rather than artificial volume addition. Profhilo’s bio-remodelling creates comprehensive skin quality improvement, whilst polynucleotides work at the cellular level to promote repair and regeneration that counteracts aging processes.
Skin Texture and Tone
Profhilo tends to provide more immediate improvement in skin texture and smoothness through its bio-remodelling action. Polynucleotides create gradual but often more profound improvements in overall skin health and resilience.
Suitability Considerations
Ideal Profhilo Candidates
Profhilo suits patients seeking overall skin quality improvement, those with skin laxity or dehydration, patients wanting natural facial rejuvenation without volume change, and individuals seeking preventative anti-aging treatments. The treatment is particularly effective for patients with good underlying skin health who want enhancement and maintenance.
Ideal Polynucleotide Candidates
Polynucleotides benefit patients with damaged or compromised skin, those seeking cellular repair and regeneration, patients with circulation concerns affecting skin health, and individuals wanting long-term skin health improvement. The treatment excels for patients needing repair of existing damage or cellular dysfunction.
Age and Skin Type Factors
Dr. Goziem’s expertise, recognised through her awards as Best Anti-Aging Practitioner Central London 2024 and 2025, ensures appropriate treatment selection based on individual skin characteristics, age, and aesthetic goals rather than one-size-fits-all approaches.
Treatment Areas and Applications
Facial Applications
Both treatments work excellently for facial rejuvenation, though Profhilo may provide more immediate overall skin quality improvement whilst polynucleotides excel in addressing specific damage or cellular dysfunction areas.
Neck and Décolletage
Both treatments effectively address these delicate areas, with Profhilo providing excellent hydration and bio-remodelling, whilst polynucleotides offer superior cellular repair for sun-damaged or aged skin in these regions.
Under-Eye Concerns
Polynucleotides often excel for under-eye dark circles and skin quality issues due to their circulation-enhancing properties, whilst Profhilo provides excellent overall skin quality improvement in the periorbital area.
Safety Profiles and Considerations
Profhilo Safety
Profhilo has an excellent safety profile with minimal risk of adverse reactions due to its high bio-compatibility and absence of chemical cross-linking agents. Most patients experience only mild, temporary swelling or redness.
Polynucleotide Safety
Polynucleotides also have an excellent safety profile when administered by qualified practitioners. The treatment’s bio-compatibility and natural mechanism of action contribute to minimal risk of complications.
Professional Administration Importance
Dr. Goziem’s membership in the Joint Dental Faculties of the Royal College of Surgeons England reflects the medical standards essential for safe administration of either treatment, ensuring optimal outcomes whilst maintaining patient safety.
Cost and Value Considerations
Treatment Investment
Both treatments represent investments in long-term skin health rather than temporary cosmetic fixes. The choice between them should be based on individual skin needs and goals rather than cost alone.
Long-term Value
Both treatments provide lasting benefits that extend beyond the presence of the injected material, creating genuine improvement in skin health and function that offers excellent long-term value.
Maintenance Requirements
Both treatments require periodic maintenance, though individual schedules vary based on skin response and aesthetic goals. Professional guidance helps determine optimal maintenance protocols for sustained benefits.
Combination Possibilities
Synergistic Approaches
In some cases, combining both treatments can provide comprehensive benefits that address multiple skin concerns simultaneously. Dr. Goziem’s expertise allows for strategic treatment planning that maximises benefits whilst ensuring safety and compatibility.
Sequential Treatment Planning
Some patients benefit from sequential treatments, using one approach to address primary concerns before introducing the other for complementary benefits. Professional assessment determines optimal treatment sequencing.
Making the Right Choice
Professional Assessment Importance
Choosing between Profhilo and polynucleotides requires professional assessment of individual skin characteristics, concerns, goals, and lifestyle factors. Dr. Goziem’s comprehensive evaluation ensures appropriate treatment selection for optimal outcomes.
Personalised Recommendations
Rather than following trends or generic advice, treatment selection should be based on thorough professional assessment that considers unique individual factors and desired outcomes.
Realistic Expectations
Both treatments provide excellent results when appropriately selected and administered, but understanding their different mechanisms and benefits ensures realistic expectations and optimal satisfaction.
Frequently Asked Questions
Q: Can I have both Profhilo and polynucleotides? A: Yes, these treatments can be combined or used sequentially when professionally planned to address different aspects of skin health and rejuvenation.
Q: Which treatment provides faster results? A: Profhilo often provides more immediate hydration benefits, whilst polynucleotides focus on longer-term cellular improvement, though both develop progressive benefits over time.
Q: How do I choose between these treatments? A: Professional consultation with comprehensive skin assessment is essential to determine which treatment best addresses your individual skin needs and aesthetic goals.
Q: Are the results from both treatments natural-looking? A: Yes, both treatments work through natural mechanisms to improve skin quality rather than adding artificial volume or changing facial structure.
Ready to discover which advanced regenerative treatment is right for your skin? Dr. Goziem and the team at Alcove Aesthetics provide expert assessment and personalised recommendations for Profhilo and polynucleotide treatments. Book your consultation at our St James clinic by calling 07856962248 or booking online to explore these revolutionary approaches to skin rejuvenation.
