Polynucleotides vs Exosomes: Which Skin Rejuvenation Treatment Is Right for You?

In the ever-evolving world of aesthetic medicine, skin regeneration treatments are advancing faster than ever. Two of the most powerful innovations on the market today are polynucleotides and exosomes – both offering remarkable improvements in skin tone, texture, and elasticity. But how do they compare? And which is right for you?

Dr Goziem, award-winning practitioner and founder of Alcove Aesthetics in Pall Mall, breaks it down.


What Are Polynucleotides?

Polynucleotides are fragments of DNA that work beneath the skin’s surface to stimulate regeneration, hydration, and collagen production.

How they work:

  • Encourage tissue repair at a cellular level
  • Stimulate fibroblasts to increase collagen and elastin
  • Reduce inflammation and improve skin quality over time

Ideal for:

  • Under-eye hollows
  • Crepey or thinning skin
  • Skin needing subtle rejuvenation

Results:

  • Gradual improvement in texture and tone over 4–6 weeks
  • Best results seen after a course of 3 sessions

Prices at Alcove Aesthetics:

  • £330 per session
  • £900 for a package of 3

What Are Exosomes?

Exosomes are nano-sized vesicles derived from stem cells. They deliver potent growth factors and signaling molecules directly to skin cells, accelerating healing and boosting skin renewal.

How they work:

  • Carry over 800 growth factors and proteins
  • Enhance collagen synthesis and skin repair
  • Reduce pigmentation, dullness, and fine lines

Ideal for:

  • Dull, tired skin
  • Advanced ageing signs
  • Post-microneedling glow enhancement

Results:

  • Fast-acting skin brightening and firming
  • Cumulative results with multiple sessions

Prices at Alcove Aesthetics:

  • £450 per session
  • £1350 for a package of 3

Which Should You Choose?

It depends on your skin needs and goals:

ConcernBest Option
Under-eye crepinessPolynucleotides
Dull or sagging skinExosomes
Fine lines & early ageing signsPolynucleotides
Skin glow post-microneedlingExosomes (add-on)

In many cases, combining both treatments leads to the most profound skin transformation. At Alcove Aesthetics, we personalise every protocol to your skin’s condition and timeline.


Under-Eye Treatment Packages

Looking specifically to treat dark circles and tired under-eyes?

We offer:

  • Filler: £410
  • Polynucleotides: £310 per session
  • Exosomes: £450 per session
  • Skin Boosters: From £250

Ready to Find the Right Treatment?

Book your personalised skin consultation online today and let Dr Goziem design the perfect plan for your goals. Alcove Aesthetics is proudly based at 120 Pall Mall, SW1Y 5EA serving Central London with doctor-led, luxury skin care solutions that work.


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120 Pall Mall, London, SW1Y 5EA

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