If you are deciding between polynucleotides and PRP for skin rejuvenation in Mayfair or Central London, the answer depends on your skin concerns and desired results. Both treatments are regenerative and work by improving skin quality rather than masking ageing. However, they function in different ways. Polynucleotides focus on deep skin repair and hydration, while PRP uses your body’s own growth factors to stimulate collagen and healing. At Alcove Aesthetics by Dr Goziem on Pall Mall, both treatments are offered as doctor-led solutions tailored to natural, long-term results.
Introduction
Many patients today are moving away from traditional fillers and seeking treatments that improve skin from within. Concerns such as fine lines, dullness, and under-eye shadows are best addressed with regenerative approaches that support collagen and skin health.
This is where polynucleotides and PRP stand out. Both are popular in a facial aesthetics clinic in London because they deliver subtle, refined results without changing your natural features.
What It Is & How It Works
Polynucleotides and PRP are both advanced regenerative treatments, but they work in different ways.
Polynucleotides are derived from purified DNA fragments. When injected into the skin, they stimulate fibroblasts, boost collagen production, and deeply hydrate the skin. They also have anti-inflammatory properties, making them ideal for delicate areas such as under the eyes.
PRP, on the other hand, uses a sample of your own blood. The blood is processed to extract platelet-rich plasma, which contains growth factors that promote healing, improve circulation, and stimulate collagen production.
At Alcove Aesthetics by Dr Goziem, both treatments are performed with medical precision, ensuring safety and optimal results.
In some cases, PRP is combined with Microneedling to enhance absorption and improve overall skin rejuvenation.
Key Differences
- Source
Polynucleotides are bio-derived molecules
PRP is taken from your own blood - Primary action
Polynucleotides focus on hydration and tissue repair
PRP focuses on regeneration and collagen stimulation - Best areas
Polynucleotides are excellent for under-eyes and thin skin
PRP works well across the full face
Benefits & Results
Both treatments offer natural-looking improvements, but their benefits differ slightly.
Polynucleotides:
- Deep hydration and improved skin elasticity
- Smoother, firmer skin
- Reduced inflammation and redness
- Excellent for under-eye rejuvenation
PRP:
- Improved skin tone and radiance
- Reduction in fine lines
- Enhanced collagen production
- Brighter under-eye area
| Concern | Best Option |
|---|---|
| Under-eye crepey skin | Polynucleotides |
| Dull complexion | PRP |
| Fine lines | Both |
| Sensitive skin | Polynucleotides |
Why Choose Alcove Aesthetics
Alcove Aesthetics by Dr Goziem is a leading doctor-led aesthetic clinic in Central London, located at 120 Pall Mall in the heart of Mayfair.
All treatments are performed by Dr Goziem Onuchukwu, BDS, MSc (Aesthetic Medicine), a GDC registered practitioner with over 7 years of experience and more than 1,000 patients treated.
Her approach is centred on subtle, natural enhancement using advanced regenerative techniques. Patients trust her expertise for results that look refreshed and balanced.
The clinic has been recognised with:
- Best Anti-Ageing Practitioner (Central London 2024 and 2025)
- Skin Aesthetics Specialist of the Year 2025
Treatment Journey
Your journey begins with a detailed consultation at this Mayfair aesthetic clinic.
Consultation
Dr Goziem assesses your skin, discusses your concerns, and recommends whether polynucleotides, PRP, or a combination approach is best.
Treatment
Both treatments are performed with precision and care. Sessions typically take around 45 to 60 minutes.
Follow-up
Follow-ups are included to monitor your progress and ensure optimal results.
In some cases, a combined approach may be recommended, using PRP alongside treatments like Sculptra for more advanced collagen stimulation.
Recovery & Aftercare
Both treatments involve minimal downtime.
- Mild swelling or redness may occur for 24 to 48 hours
- Bruising is possible but usually minimal
- Skin may feel slightly sensitive
Results develop gradually over several weeks, with continued improvement as collagen production increases.
Aftercare guidance is provided, and follow-ups are included with all treatments.
Cost & Transparency
At Alcove Aesthetics, pricing is clear and reflects the quality of doctor-led care.
- Polynucleotides – £330 per session or £900 for 3
- PRP – £350 per session or £950 for 3
A £50 booking fee is required and is redeemable against treatment. A 48-hour reschedule policy applies.
A consultation is essential to determine the most suitable treatment plan for your skin.
FAQs
Which is better, polynucleotides or PRP?
It depends on your concern. Polynucleotides are often better for hydration and under-eye treatment, while PRP is ideal for overall skin rejuvenation.
Can I combine both treatments?
Yes, many patients benefit from combining polynucleotides and PRP for enhanced results.
Are the results natural?
Yes, both treatments work with your body to improve skin quality gradually and naturally.
How many sessions will I need?
A course of three sessions is typically recommended for both treatments.
Are these treatments safe?
Yes, when performed by a qualified medical professional, both treatments are considered very safe.
Both polynucleotides and PRP are excellent options for skin rejuvenation in a facial aesthetics clinic in London. The right choice depends on your skin type, concerns, and goals.
To book your personalised consultation with Dr Goziem Onuchukwu at Alcove Aesthetics, Pall Mall, London, call 07856962248 or book online at alcoveaesthetics.com/appointments.
